C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 401/00 (2006.01) A61K 31/593 (2006.01) C07C 49/443 (2006.01)
Patent
CA 2531505
The compound (20S)-1 .alpha.-hydroxy-2-methylene-19-nor-vitamin D3 and pharmaceutical uses therefor are described herein. This compound exhibits pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti~cancer agent and for the tretment of skin diseases such as psoriasis as well as skin conditions such as wrinkles, slack skin, dry skin and insufficient sebum secretion. This compound also has very significant calcemic activity and therefore may be used to treat immune disorders in humans as well as metabolic bone diseases such as osteoporosis.
L'invention concerne un composé de la (20S)-1.alpha.-hydroxy-2-methylene-19-nor-vitamine D¿3? et ses utilisations pharmaceutiques. Ledit composé présente une activité prononcée d'arrêt de la prolifération des cellules indifférenciées et d'amorçage de leur différenciation en monocytes, justifiant ainsi son utilisation comme agent anticancéreux et de traitement des maladies cutanées telles que le psoriasis ainsi que de problèmes cutanés tels que rides, relâchement de la peau, sécheresse cutanée, et sécrétion insuffisante de sébum. Ce composé présente en outre une importante activité calcémique et peut par conséquent servir à traiter les troubles immunitaires chez les patients humains ainsi que les maladies osseuses métaboliques telles que l'ostéoporose.
Deluca Hector F.
Grzywacz Pawel K.
Sicinski Rafal R.
Borden Ladner Gervais Llp
Wisconsin Alumni Research Foundation
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