C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 225/06 (2006.01) A61K 31/395 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2628728
The present invention relates to 21-deoxymacbecin analogues that are useful, e.g. in the treatment of cancer, B-cell malignancies, malaria, fungal infection, diseases of the central nervous system and neurodegenerative diseases, diseases dependent on angiogenesis, autoimmune diseases or as a prophylactic pretreatment for cancer. The present invention also provides methods for the production of these compounds and their use in medicine, in particular in the treatment and / or prophylaxis of cancer or B-cell malignancies.
La présente invention concerne des analogues de la 21-deoxymacbécine qui sont notamment utiles dans le traitement du cancer, des affections malignes touchant les lymphocytes B, de la malaria, des infections fongiques, des maladies du système nerveux central et des maladies neurodégénératives, des maladies liées à l~angiogenèse, des maladies auto-immunes ou en tant que traitement prophylactique du cancer. La présente invention concerne également des procédés permettant la production de ces composés ainsi que leur utilisation en médecine, en particulier dans le traitement et/ou la prophylaxie du cancer ou des affections malignes touchant les lymphocytes B.
Gaisser Sabine
Lill Rachel Edith
Martin Christine Janet
Nur-E-Alam Mohammed
Sheehan Lesley Sarah
Biotica Technology Ltd.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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