21-hydroxy-6,19-oxidoprogesterone (21oh-6op) and its use as...

A - Human Necessities – 61 – K

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A61K 31/58 (2006.01) A61P 5/46 (2006.01) A61P 25/24 (2006.01)

Patent

CA 2303817

The comformationally highly bent steroid 21-hydroxy-6,19- oxidoprogesterone (21OH- 60P) has been found to be a selective antiglucocorticoid virtually lacking mineralococorticoid or glucocorticoid properties as well as affinity for MR or PR and is used for the treatment of diseases associated with an excess of glucocorticoids in the body, such as the Cushing's syndrome or depression.

On a découvert que le stéroïde à conformation fortement courbée 21-hydroxy-6,19-oxydoprogestérone (21OH-6OP) est un antiglucocorticoïde sélectif manquant totalement de propriétés minéralocorticoïdes ou glucocorticoïdes, ainsi que de l'affinité pour le récepteur minéralocorticoïde (MR) ou pour le récepteur de la progestérone (PR). Ladite substance est utilisée pour traiter des maladies associées à un excès de glucocorticoïdes dans le corps, telles que le syndrome de Cushing ou la dépression.

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