A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 38/13 (2006.01) A61K 38/17 (2006.01) A61K 38/18 (2006.01) A61K 38/19 (2006.01) C07K 16/22 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2298737
The invention provides a method for reducing formation or progression of neoplasms associated with immunosuppressive therapy in a mammal, the method comprising treating the mammal with an effective amount of a TGF-.beta. antagonist. Also provided are compositions comprising a TGF-.beta. antagonist and an immunosuppressive agent such as cyclosporin or FK506. The TGF-.beta. antagonists of the invention include proteins and polypeptides that bind TGF-.beta. receptors, anti-TGF-.beta. antibodies, TGF-.beta. receptors and fragments thereof. In another aspect the invention provides methods for identifying compounds capable of inhibiting the formation or proliferation of tumors in a mammal undergoing immunosuppressive therapy.
Hojo Minoru
Suthanthiran Manikkam
Cornell Research Foundation Inc.
Smart & Biggar
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