23-oxo (keto) and 23-imino derivatives of mono- and diepoxy...

Details 23-oxo (keto) and 23-imino derivatives of mono- and diepoxy... 23-oxo (keto) and 23-imino derivatives of mono- and diepoxy...

C - Chemistry, Metallurgy

07

D

167/202, 260/228

C07D 493/22 (2006.01) A01N 43/90 (2006.01) A01N 47/24 (2006.01) A01N 47/34 (2006.01) A61K 31/365 (2006.01)

Patent

CA 1301165

?30,522 23-OXO (KETO) AND 23-IMINO DERIVATIVES OF MONO- AND DIEPOXY LL-F28249 COMPOUNDS ABSTRACT The present invention relates to novel 23-oxo (keto) and 23-imino derivatives of certain C(26,27)- epoxy- and C(14,15:26,27)-diepoxy-LL-F28249 compounds. The LL-F28249 compounds (collectively) are isolates from the fermentation broth of Streptomyces cyaneogriseus subspecies noncyanogenus having deposit accession no. NRRL-15773. The derivatives are obtained by oxidation of the 23-hydroxy group of 5-O-silylated- C(26,27)-epoxy and C(14,15;26,27)diepoxy-LL-F28249 compounds, followed by desilylation and derivatization with amino compounds. The novel compounds have anthel- mintic, ectoparasiticidal, nematicidal, insecticidal and acaricidal activity and are, therefore, useful in the treatment of infections in warm-blooded animals and infestations in agricultural crops. Compositions containing the present compounds as active ingredients thereof also are presented.

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