24,24-difluoro-25-hydroxycholecalciferol

Details 24,24-difluoro-25-hydroxycholecalciferol 24,24-difluoro-25-hydroxycholecalciferol

C - Chemistry, Metallurgy

07

J

204/91.05, 260/6

C07J 9/00 (2006.01)

Patent

CA 1157049

Abstract The invention provides a new derivative of vitamin D3, 24,24- difluoro-25-hydroxycholecalciferol. The compound is characterized by vitamin D-like activity in its ability to increase intestinal calcium transport, increase serum calcium and inorganic phosphorous concentration and to prevent the development of rickets. It would find ready application as a substi- tute for vitamin D3 and in the treatment of disease states evincing calcium-phosphorous imbalance and which are non-responsive to vitamin D3 therapy.

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