24-and 25-substituted avermectin and milbemycin derivatives

Details 24-and 25-substituted avermectin and milbemycin derivatives 24-and 25-substituted avermectin and milbemycin derivatives

C - Chemistry, Metallurgy

07

H

167/202, 260/210

C07H 17/08 (2006.01) A01N 43/90 (2006.01) A61K 31/70 (2006.01) C07H 19/01 (2006.01) C07H 23/00 (2006.01)

Patent

CA 2028763

CASE 18031 ABSTRACT OF THE DISCLOSURE Novel avermectin and milbemycin derivatives are disclosed, where the C-24 and C-25 carbon atoms are substituted by hydrogen, alkyl, alkenyl, substituted alkyl or substituted alkenyl groups. These compounds can be further substituted at the 4"-, 5-, 13-, and 23- positions. The new C-24 and C-25 substituted avermectin and milbemycin derivatives are prepared by cleavage of known and suitably protected avermectin and milbemycin compounds. The new compounds are potent anti-parasitic agents, in particular, the compounds are anthelmintic, insecticidal and acaricidal agents.

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