24-homo-26,27-hexafluoro-cholecalciferols

C - Chemistry – Metallurgy – 07 – C

Patent

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Details

C07C 401/00 (2006.01) A61K 31/59 (2006.01) C07C 35/52 (2006.01) C07F 7/18 (2006.01)

Patent

CA 2235584

The invention relates to a compound of formula (I) wherein A is a carbon double bond having the stereochemical configuration E or Z, i.e. of formula (a) or (b), respectively, R is hydroxy and R1 is hydrogen or =CH2 or R is hydrogen or fluoro and R1 is =CH2. Compounds of formula (I) induce differentiation and inhibition of proliferation in certain skin and cancer cell lines. Accordingly, the compounds of formula (I) are useful as agents for the treatment of hyperproliferative skin diseases such as psoriasis. Compounds of formula (I) are also useful as agents for the treatment of neoplastic diseases, such as leukemia.

L'invention concerne un composé de la formule (I) dans laquelle A représente une liaison carbone double correspondant à la configuration stéréochimique E ou Z, c'est-à-dire respectivement à la formule (a) ou (b), R représente hydroxy et R?1¿ représente hydrogène ou =CH¿2?, ou bien R représente hydrogène ou fluoro et R?1¿ représente =CH¿2?. Des composés répondant à la formule (I) induisent une différenciation ainsi qu'une inhibition de la prolifération dans certaines lignées cellulaires cutanées ou cancéreuses. En conséquence, ces composés sont utiles en tant qu'agents destinés au traitement de maladies de la peau à hyperprolifération, telles que le psoriasis, et ils sont également utiles en tant qu'agents destinés au traitement de maladies néoplasiques telles que la leucémie.

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