24-sulfoximine vitamin d3 compounds

Details 24-sulfoximine vitamin d3 compounds 24-sulfoximine vitamin d3 compounds

C - Chemistry, Metallurgy

07

C

C07C 401/00 (2006.01) A61K 31/59 (2006.01) A61K 31/593 (2006.01) A61P 3/02 (2006.01) A61P 5/18 (2006.01) A61P 17/00 (2006.01) A61P 17/06 (2006.01) A61P 19/00 (2006.01) A61P 19/10 (2006.01) A61P 35/00 (2006.01) A61P 37/06 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2488334

The present invention provides novel sulfoximine compounds, compositions comprising these compounds and methods of using these compounds as inhibitors of CYP24. In particular, the compounds of the invention are useful for treating diseases which benefit from a modulation of the levels of 1.alpha.,25- dihydroxy vitamin D3, for example, cell-proliferative disorders.

L'invention se rapporte à de nouveaux composés sulfoximine, à des compositions comprenant ces composés ainsi qu'à des procédés d'utilisation de ces composés en tant qu'inhibiteurs de l'enzyme CYP24. En particulier, les composés selon la présente invention peuvent servir à traiter des maladies contre lesquelles une modulation des niveaux de la 1.alpha.,25-dihydroxy vitamine D¿3? peut être bénéfique, telles que des troubles de la prolifération cellulaire.

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