25-hydroxy-16-ene-26,27-bishomo-cholecalciferols

Details 25-hydroxy-16-ene-26,27-bishomo-cholecalciferols 25-hydroxy-16-ene-26,27-bishomo-cholecalciferols

C - Chemistry, Metallurgy

07

C

C07C 401/00 (2006.01) A61K 31/59 (2006.01) C07C 35/32 (2006.01) C07C 45/29 (2006.01) C07C 45/30 (2006.01) C07C 49/513 (2006.01)

Patent

CA 2237897

The invention relates to a compound of formula (1] wherein A is a carbon- carbon double bond having the E or Z stereochemical configuration, or A is a carbon-carbon triple bond, Et is ethyl, and R is hydroxy and R1 is hydrogen or =CH2, or R is hydrogen or fluoro and R1 is =CH2. They stimulate HL-60 cell differentiation and accordingly, are useful as agents for the treatment of neoplastic diseases, such as leukemia.

L'invention concerne un composé de la formule (I) dans laquelle A représente une liaison double carbone-carbone possédant la configuration stéréochimique E ou Z, ou bien A représente une liaison triple carbone-carbone, E représente éthyle, R représente hydroxy et R<1> représente hydrogène ou =CH2, ou bien R représente hydrogène ou fluoro et R<1> représente =CH2. Ces composés stimulent la différenciation des cellules HL-60 et ils sont utiles en tant qu'agents de traitement de maladies néoplasiques, telles que la leucémie.

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