25-hydroxyvitamin d3-1.alpha.-hydroxylase and dna encoding...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/53 (2006.01) C07K 16/40 (2006.01) C12N 9/02 (2006.01) C12P 7/22 (2006.01) G01N 33/573 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2237138

The present invention relates to a polypeptide having 25-hydroxyvitamin D3-1.alpha.-hydroxylase activity, being useful for the prevention, diagnosis and therapeutic treatment of adult diseases such as osteoporosis induced by the decrease of active type vitamin D3 and catalyzing the final stage of vitamin D3 activation; and the gene encoding the polypeptide. In accordance with the present invention, the following can be provided; a polypeptide having 25-hydroxyvitamin D3-1.alpha.-hydroxylase activity, DNA encoding the polypeptide, a recombinant DNA prepared by inserting the DNA in a vector, a transformant carrying the recombinant DNA, a method for preparing 25-hydroxyvitamin D3-1.alpha.-hydroxylase by using the transformant, a method for preparing 1.alpha., 25-dihydroxyvitamin D3 comprising using the polypeptide having 25-hydroxyvitamin D3-1.alpha.-hydroxylase activity, and an antibody recognizing the polypeptide.

L'invention concerne un polypeptide ayant l'activité de la 25-hydroxyvitamine D3-1.alpha.-hydroxylase, utile pour prévenir, diagnostiquer et traiter les maladies chez les adultes, comme l'ostéoporose provoquée par la diminution de la vitamine D3 active, et pour catalyser la dernière étape de l'activation de la vitamine D3; et le gène codant pour le polypeptide. L'invention fournit : un polypeptide ayant l'activité de la 25-hydroxyvitamine D3-1.alpha.-hydroxylase, de l'ADN codant pour le polypeptide, un ADN recombiné préparé par insertion de l'ADN dans un vecteur, un transformant portant l'ADN recombiné, une méthode de préparation de la 25-hydroxyvitamine D3-1.alpha.-hydroxylase au moyen du transformant, une méthode de préparation de la 1.alpha., 25-hydroxyvitamine D3 consistant à utiliser le polypeptide ayant l'activité de la 25-hydroxyvitamine D3-1.alpha.-hydroxylase et un anticorps reconnaissant le polypeptide.

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