25-hydroxyvitamin d3 24-hydroxylase transgenic animals

A - Human Necessities – 01 – K

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A01K 67/027 (2006.01) C12N 5/00 (2006.01) C12N 9/02 (2006.01) C12N 15/53 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2287979

Transgenic non-human mammals which are usable as pathological animal models of kidney diseases, bone diseases, joint diseases, lung diseases, hyperlipemia, arteriosclerosis, heart diseases, diabetes, obesity, diagnostic diseases, infections, allergic diseases, endocrine diseases, dementia, cancer or complications of these diseases and enable the clarification of the pathologic mechanisms of these diseases, examination on the therapeutics therefore and screening of remedies therefore.

Mammifères transgéniques pouvant être utilisés comme modèles pathologiques animaux pour les maladies des reins, des os, des articulations, des poumons, l'hyperlipémie, l'artériosclérose, les maladies cardiaques, le diabète, l'obésité, les maladies digestives, les infections, les maladies allergiques, endocrines, la démence, le cancer ou des complications de ces maladies. Ces animaux permettent en outre d'éclaircir les mécanismes pathologiques de ces maladies, d'étudier les traitements pour ces dernières et de sélectionner des médicaments pour ces maladies.

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