25-methylene and 24,25-epoxy marcfortines and paraherquamides

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 491/22 (2006.01) A61K 31/55 (2006.01)

Patent

CA 2264052

The present invention are marcfortines and paraherquamides where the 7-member oxygenated ring has been modified to produce 25-methylene compounds (VII) and 24,25-epoxy compounds (VIII) all of which are useful as antiparasitic agents against endo and ecto parasites, particularly helminths and arthropods.

La présente invention concerne des marcfortines et des paraherquamides dans lesquels on a modifié le noyau oxygéné à 7 chaînons, afin de produire des composés 25-méthylène (VII) et des composés 24,25-époxy (VIII), tous ces composés étant utiles en tant qu'agents antiparasitaires dirigés contre des endoparasites et des ectoparasites, notamment des helminthes et des arthropodes.

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