C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 401/00 (2006.01) A61K 31/593 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2510228
The present invention provides novel D-ring and side-chain analogs of l.alpha.,25-dihydroxyvitamin D3, compositions comprising these compounds and methods of using these compounds as selective inhibitors of CYP24. In particular, the compounds of the invention are useful for treating diseases which benefit from a modulation of the levels of l.alpha.,25-dihydroxyvitamin D3, for example, cell-proliferative disorders.
La présente invention concerne des analogues à cycle D et à chaînes latérales de la 1.alpha.,25-dihydroxyvitamine D¿3?, des compositions renfermant ces composés et des méthodes d'utilisation de ces composés comme inhibiteurs sélectifs de la CYP24. Les composés de l'invention sont utiles en particulier pour le traitement de maladies présentant une modulation des taux de la 1.alpha.,25-dihydroxyvitamine D¿3?, telles que les troubles impliquant une prolifération cellulaire.
Crawford Kenneth R.
Jeon Heung Bae
Jones Glenville
Lee Jae Kyoo
Posner Gary H.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Cytochroma Inc.
Johns Hopkins University
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