29 human cancer associated proteins

Details 29 human cancer associated proteins 29 human cancer associated proteins

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/02 (2006.01) A61K 38/16 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12N 15/66 (2006.01) C12P 21/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2382729

This invention relates to newly identified cancer related polynucleotides and the polypeptides encoded by these polynucleotides herein collectively known as "cancer antigens" or "cancer related proteins", and the use of such cancer antigens for detecting cancer and cancer metastases. This invention relates to cancer antigens as well as vectors, host cells, antibodies directed to cancer antigens and the recombinant methods and synthetic methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of cancer antigens of the invention. The present invention further relates to inhibiting the production and function of the polypeptides of the present invention.

La présente invention concerne des ploynucléotides et les polypeptides codés par ces polynucléotides connus collectivement sous le nom de <= antigènes du cancer >= ou <= protéines liées au cancer>= récemment identifiés et associés au cancer. Cette invention porte également sur l'utilisation de tels antigènes de cancer pour détecter un cancer ou des métastases cancéreuses. Ladite invention concerne aussi bien les antigènes du cancer que les vecteurs, les cellules hôtes, les anticorps dirigés contre les antigènes du cancer et des procédés recombinants et synthétiques de production de ces anticorps. L'invention porte en outre sur des procédés de criblage automatique visant à identifier des agonistes et des antagonistes des antigènes du cancer selon la présente invention, sur l'inhibition de la production et de la fonction des polypeptides selon la présente invention.

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