2h-¬1|benzoxepino¬5,4-b|1,4-oxazine derivatives

Details 2h-¬1|benzoxepino¬5,4-b|1,4-oxazine derivatives 2h-¬1|benzoxepino¬5,4-b|1,4-oxazine derivatives

C - Chemistry, Metallurgy

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D

167/215, 260/244

C07D 498/04 (2006.01) A61K 31/535 (2006.01) C07D 313/08 (2006.01) C07D 498/14 (2006.01)

Patent

CA 1236833

ABSTRACT OF THE DISCLOSURE Derivatives of 2H-[1]benzoxepino[5,4-b]-1,4-oxazine, such as trans-(4a,11b)-3,4,4a,5,6,11b-hexahydro-10-methoxy- 2H-[l]benzoxepino[5,4-b]-1,4-oxazine, are prepared by acylating a trans-4-amino-2,3,4,5-tetrahydro-1-benzoxepin- 5-ol, cyclizing the resulting chloroacetamido alcohol, reducing the 1,4-oxazine-3(4H)-one so obtained, acylating the resulting 2H-[1]benzoxepino[5,4-b]-1,4-oxazine, and reducing the N-acyl-2H-[1]benzoxepino[5,4-b]-1,4-oxazine so obtained. The novel compounds disclosed herein possess useful antihypertensive properties.

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