2h-¬1|benzoxepino¬5,4-b|-1,4-oxazine derivatives

Details 2h-¬1|benzoxepino¬5,4-b|-1,4-oxazine derivatives 2h-¬1|benzoxepino¬5,4-b|-1,4-oxazine derivatives

C - Chemistry, Metallurgy

07

D

167/215, 260/244

C07D 498/04 (2006.01) C07D 313/08 (2006.01) C07D 498/14 (2006.01)

Patent

CA 1236100

ABSTRACT OF THE DISCLOSURE Derivatives of 2H-[l]benzoxepino[5,4-b]-1,4-oxazine, such as (4a,11b)-3,4,4a,5,6,11b-hexahydro-2H-[l]benzoxe- pino[5,4-b]-1,4-oxazine, are prepared by acylating a 4-amino-2,3,4,5-tetrahydro-1-benzoxepin-5-ol, cyclizing the resulting chloroacetamido alcohol, reducing the 1,4-oxazine-3(4H)-one so obtained, acylating the resulting 2H-[l]benzoxepino[5,4-b]-1,4-oxazine, and reducing the N-acyl-2H-[l]benzoxepino[5,4-b]-1,4-oxazine so obtained. The novel compounds disclosed herein possess useful muscle relaxant and analgesic properties. C-31,292A

447246

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