2h-benzo[b][1,4]oxazin-3(4h)-one derivatives for use as...

Details 2h-benzo[b][1,4]oxazin-3(4h)-one derivatives for use as... 2h-benzo[b][1,4]oxazin-3(4h)-one derivatives for use as...

A - Human Necessities

61

K

A61K 31/538 (2006.01) A61P 3/00 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 9/00 (2006.01) A61P 9/04 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01) A61P 35/00 (2006.01) C07D 265/36 (2006.01)

Patent

CA 2719376

The present invention discloses 2H-benzo[b][1,4]oxazin-3(4H)-one derivatives for use as inhibitors of stearoyl-CoA desaturase having the structure of Formula I. The compounds are useful in treating and/or preventing various human diseases, mediated by stearoyl-CoA desaturase (SCD) enzymes, especially diseases related to abnormal lipid levels, cardiovascular disease, diabetes, obesity, metabolic syndrome and the like.

La présente invention concerne des dérivés de 2H-benzo[b][1,4]oxazin-3(4H)-one à utiliser comme inhibiteurs de la stéaroyl-CoA désaturase ayant la structure donnée par la formule I. Les composés sont utiles pour le traitement et/ou la prévention de diverses maladies humaines, à médiation par des enzymes stéaroyl-CoA désaturase (SCD), en particulier les maladies associées à des taux lipidiques anormaux, une maladie cardiovasculaire, le diabète, lobésité, le syndrome métabolique et des maladies similaires.

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