2h-chromene compound and derivative thereof

Details 2h-chromene compound and derivative thereof 2h-chromene compound and derivative thereof

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/397 (2006.01) A61K 31/4025 (2006.01) A61K 31/403 (2006.01) A61K 31/404 (2006.01) A61K 31/41 (2006.01) A61K 31/4155 (2006.01) A61K 31/427 (2006.01) A61K 31/4433 (2006.01) A61K 31/4436 (2006.01) A61K 31/4439 (2006.01) A61K 31/453 (2006.01) A61P 1/00 (2006.01) A61P 1/16 (2006.01) A61P 1/18 (2006.01) A61P 3/10 (2006.01) A61P 9/10 (2006.01) A61P 11/00 (2006.01) A61P 11/06 (2006.01) A61P 13/12 (2006.01) A61P 17/00 (2006.01) A61P 19/02 (2006.01) A61P 21/04 (2006.01) A61P 25/00 (2006.0

Patent

CA 2745356

Disclosed is a compound which has an excellent S1P1 agonistic activity and is particularly useful as an active ingredient for a prophylactic and/or therapeutic agent for diseases induced by undesirable lymphocyte infiltration or diseases induced by abnormal proliferation or accumulation of cells. Specifically disclosed are a 2H-chromene compound and a derivative thereof, each of which has an S1P1 agonistic activity and can be used particularly for the prevention and/or treatment of diseases induced by undesirable lymphocyte infiltration or diseases induced by abnormal proliferation or accumulation of cells.

L'invention porte sur un composé qui a une excellente activité agoniste de S1P1 et qui est particulièrement utile comme ingrédient actif pour un agent prophylactique et/ou thérapeutique pour des maladies induites par une infiltration de lymphocytes indésirable ou des maladies induites par une prolifération ou une accumulation anormale de cellules. Plus particulièrement, l'invention porte sur un composé de 2H-chromène et sur un dérivé de celui-ci présentant chacun une activité agoniste de S1P1 et pouvant être utilisé en particulier pour la prévention et/ou le traitement de maladies induites par une infiltration de lymphocytes indésirables ou de maladies induites par une prolifération ou une accumulation anormale de cellules.

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