2r,4s,r,r- and 2s,4r,r,r-hydroxyitraconazole

Details 2r,4s,r,r- and 2s,4r,r,r-hydroxyitraconazole 2r,4s,r,r- and 2s,4r,r,r-hydroxyitraconazole

C - Chemistry, Metallurgy

07

D

C07D 405/14 (2006.01) A61K 31/495 (2006.01) C07D 249/12 (2006.01) C07D 405/06 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2269622

A method of preparation of optically pure isomers of hydroxyitraconazole, in particular the two cis dioxolane diastereomers of the sec-butyl R,R-isomer, and to phosphate and sulfate derivatives thereof is disclosed. Pharmaceutical compositions containing these compounds and their use for the treatment of fungal infection are also disclosed.

L'invention concerne un procédé pour préparer des isomères optiquement purs d'hydroxy-itraconazole, en particulier les deux diastéréomères de cis dioxolanne de l'isomère sec-butyle R,R, et pour réaliser la phosphatation et la sulfatation des dérivés desdits isomères. L'invention concerne également des compositions pharmaceutiques renfermant ces composés, et leur utilisation dans le traitement de l'infection fongique.

Affiliated with

Also associated with

Rating

2r,4s,r,r- and 2s,4r,r,r-hydroxyitraconazole does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 2r,4s,r,r- and 2s,4r,r,r-hydroxyitraconazole, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 2r,4s,r,r- and 2s,4r,r,r-hydroxyitraconazole will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1454622