3-(1-[3-(1,3-benzothiazol-6-yl)propylcarbamoyl]cycloalkyl)pr...

Details 3-(1-[3-(1,3-benzothiazol-6-yl)propylcarbamoyl]cycloalkyl)pr... 3-(1-[3-(1,3-benzothiazol-6-yl)propylcarbamoyl]cycloalkyl)pr...

C - Chemistry, Metallurgy

07

D

C07D 277/64 (2006.01) A61K 31/428 (2006.01) A61P 15/00 (2006.01)

Patent

CA 2519072

The invention relates to inhibitors of neutral endopeptidase enzyme (NEP) of formula (I), uses thereof, processes for the preparation therof, intermediates used in the preparation thereof and compositions containing said inhibitors. These inhibitors have utility in a variety of therapeutic areas including the treatment of male and female sexual dysfunction, particularly female sexual dysfunction (FSD), especially wherein the FSD is female sexual arousal disorder (FSAD).

L'invention se rapporte à des inhibiteurs de l'enzyme endopeptidase neutre (NEP) répondant à la formule (I), à leurs utilisations, à des procédés pour leur préparation, à des intermédiaires utilisés dans leur préparation ainsi qu'à des compositions les contenant. Lesdits inhibiteurs peuvent être utilisés dans une variété de domaines thérapeutiques, y compris le traitement de la dysfonction sexuelle masculine et féminine, en particulier la dysfonction sexuelle féminine (FSD), plus particulièrement lorsqu'il s'agit de troubles de l'excitation sexuelle chez la femme (FSAD).

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