3-(1-naphthyl)-2-cyanopropanoic acid derivatives as estrogen...

Details 3-(1-naphthyl)-2-cyanopropanoic acid derivatives as estrogen... 3-(1-naphthyl)-2-cyanopropanoic acid derivatives as estrogen...

A - Human Necessities

61

K

A61K 31/496 (2006.01) A61K 31/44 (2006.01) A61P 29/00 (2006.01) C07C 255/19 (2006.01) C07D 205/04 (2006.01) C07D 209/08 (2006.01) C07D 211/18 (2006.01) C07D 211/82 (2006.01) C07D 213/74 (2006.01) C07D 215/14 (2006.01) C07D 217/16 (2006.01) C07D 295/185 (2006.01)

Patent

CA 2523235

This invention provides compounds of formula (I) or a pharmaceutically acceptable salt thereof that are useful for the treatment of the inflammatory component of diseases and are particularly useful in treating atherosclerosis, myocardial infarction, congestive heart failure, inflammatory bowel disease, arthritis, type II diabetes, and autoimmune diseases such as multiple sclerosis and rheumatiod arthritis.

L'invention concerne des composés représentés par la formule (I), ou un sel pharmaceutiquement acceptable de ceux-ci. Ces composés sont utiles dans le traitement de la composante inflammatoire de maladies et sont particulièrement utiles dans le traitement de l'athérosclérose, de l'infarctus du myocarde, de l'insuffisance cardiaque globale, de la maladie intestinale inflammatoire, de l'arthrite, du diabète du type II et des maladies auto-immunes, telles que la sclérose en plaques et la polyarthrite rhumatoïde.

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