C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/264.1
C07D 403/00 (2006.01) C07D 231/38 (2006.01) C07D 403/04 (2006.01)
Patent
CA 1095912
ABSTRACT OF THE DISCLOSURE The invention relates to novel 3-(1-pyrazolyl)- pyridazine derivatives of the general formula I, or pharmaceutically acceptable acid addition salts thereof, Image (I) wherein R1 stands for a hydrogen atom or a C1-4 alkyl group, R2 stands for a hydrogen atom, a cyano, carboxyl, carbamoyl, carbazoyl or C1-4 alkoxycarbonyl group, R3 stands for a hydrogen or chlorine atom or an -NR4NHR5 group, wherein R4 and R5 stand independently from each other for a hydrogen atom or a C1-4 alkyl or an -NR5R7 group, w erein R6 and R7 stand independently from each other for a hydrogen atom or a C1-5 alkyl, C1-5 hydroxyalkyl, C3-7 cycloalkyl, phenyl or benzyl group, or a benzyl or phenylethyl group substituted by one or two chlorine atoms or methoxy groups, or a furyl- methyl, pyridylmethyl, pyrrolidine or piperazine ring, or when R7 stands for a hydrogen atom, R6 may represent a -(CH2)n-NR4R5 group, wherein, the meaning of R4 and R5 is the same as above and n represents an integer from 1 to 3. A process for preparation of the compounds of - 2 - general formula I is also within the scope of this invention. The above compounds possess valuable pharmacodynamic properties: they decrease the high blood pressure and inhibit the catabolism of prostaglandins.
305147
Cseh Gyorgy
Divald Andras
Elek Sandor
Elekes Istvan
Jaszlits Laszlo
Fetherstonhaugh & Co.
Richter Gedeon Vegyeszeti Gyar Rt
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