C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/264.1, 260/2
C07D 403/04 (2006.01) C07D 231/10 (2006.01) C07D 521/00 (2006.01)
Patent
CA 1090337
Abstract The invention relates to compounds of general formula I Image wherein R1 stands for a hydrogen atom or a C1-6 alkyl-, a C2-4 hydroxyalkyl, a C3-6 cycloalkyl or a phenyl, group, R2 stands for hydrogen, fluorine, chlorine or bromine atom or a C1-6 alkyl, a C2-4 hydroxyalkyl, a nitro or an -NR5R6 group, wherein R5 and R6 may have the same or different meaning and stand each for a hydrogen atom or a C1-4 alkyl or C2-4 hydroxy- alkyl group, R3 stands for a hydrogen atom or a C1-6 alkyl, a C2-4 hydroxyalkyl, a C3-6 cycloalkyl or a phenyl group a chlorine atom or a hydroxyl, amino or methoxy group, R4 stands for a carbamoyl, a cyano or an -NR7-NHR8 group, wherein R7 and R8 may have the same or - 2 - different meaning and stand each for a hydrogen atom or a C1-4 alkyl, a C2-4 hydroxyalkyl, a C1-4 alkoxycarbonyl or an -NR9R10 group, wherein R9 and R10 may have the same or different meaning and stand each for a hydrogen atom or a C1-5 alkyl, a C2-4 hydroxyalkyl, a C3-6 cycloalkyl, a phenyl or a benzyl group, or -NR9R10 may represent a morpholine, piperidine or piperazine ring, and their pharmaceutically acceptable acid-addition salts. Furthermore, the invention relates to a process for preparing these compounds. The novel compounds of general formula I have valuable pharmacological properties. Thus they show a considerable hypotensive effect and are capable to inhibit enzymes regulating the catabolismprostaglandins..
307397
Cseh Gyorgy
Elek Sandor
Elekes Istvan
Jaszlits Laszlo
Kasztreiner Endre
Fetherstonhaugh & Co.
Richter Gedeon Vegyeszeti Gyar Rt
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