3-¬1-thiazolidinylbutyl-4-piperazinyl|-1h-indazoles, a...

C - Chemistry – Metallurgy – 07 – D

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C07D 417/14 (2006.01) A61K 31/495 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2042982

1 HOE 90/S 009 ABSTRACT 3-[1-Thiazolidinylbutyl-4-piperazinyl]-1H-indazoles This invention relates to 3-[1-thiazolidinylbutyl4-piperazinyl]-lH-indazoles of the formula I Image (I) where R1 and R2 are each independently hydrogen or loweralkyl or R1 and R2 takentogether with the carbon atom to which they are attached form a cyclopentane, cyclohexane or cycloheptane ring; R3 and R4 are independently hydrogen or loweralkyl or R3 and R4 taken together with the carbon atom to which they are attached form a cyclopentane, cyclohexane or cycloheptane ring; R5 is hydrogen, loweralkyl, alkanoyl or aroyl; X is halogen, loweralkyl or alkoxy; m is an integer of 0 to 3, the pharmaceutically acceptable acid addition salts thereof and where applicable, the optical, geometrical and stereoisomers and racemic mixtures thereof. The compounds of this invention are useful as antipsychotic agents.

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