C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/14 (2006.01) A61K 31/495 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2042982
1 HOE 90/S 009 ABSTRACT 3-[1-Thiazolidinylbutyl-4-piperazinyl]-1H-indazoles This invention relates to 3-[1-thiazolidinylbutyl4-piperazinyl]-lH-indazoles of the formula I Image (I) where R1 and R2 are each independently hydrogen or loweralkyl or R1 and R2 takentogether with the carbon atom to which they are attached form a cyclopentane, cyclohexane or cycloheptane ring; R3 and R4 are independently hydrogen or loweralkyl or R3 and R4 taken together with the carbon atom to which they are attached form a cyclopentane, cyclohexane or cycloheptane ring; R5 is hydrogen, loweralkyl, alkanoyl or aroyl; X is halogen, loweralkyl or alkoxy; m is an integer of 0 to 3, the pharmaceutically acceptable acid addition salts thereof and where applicable, the optical, geometrical and stereoisomers and racemic mixtures thereof. The compounds of this invention are useful as antipsychotic agents.
Bordeau Kenneth
Hrib Nicholas J.
Jurcak John G.
Strupczewski Joseph T.
Aventis Pharmaceuticals Inc.
Bereskin & Parr
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