[3.2.0]bicycloheptanone oxime ethers with valuable...

Details [3.2.0]bicycloheptanone oxime ethers with valuable... [3.2.0]bicycloheptanone oxime ethers with valuable...

C - Chemistry, Metallurgy

07

C

167/255, 167/263

C07C 49/753 (2006.01) A61K 31/557 (2006.01) C07C 29/40 (2006.01) C07C 33/042 (2006.01) C07C 33/42 (2006.01) C07C 45/00 (2006.01) C07C 45/45 (2006.01) C07C 45/59 (2006.01) C07C 45/63 (2006.01) C07C 45/64 (2006.01) C07C 45/65 (2006.01) C07C 49/513 (2006.01) C07C 49/743 (2006.01) C07C 49/747 (2006.01) C07C 405/00 (2006.01) C07D 317/72 (2006.01) C07D 493/10 (2006.01) C07F 7/18 (2006.01)

Patent

CA 1248526

ABSTRACT OF THE DISCLOSURE Compounds useful in treating cardiovascular disorders are the carboxylic acids depicted in formulas (1) and (2) Image (1) Image (2) as well as their pharmaceutically acceptable, non-toxic salts and esters, wherein: n is an integer from one to four; R1 is hydroxy; R2 is hydrogen; or R1 and R2 together are an oxo group; R3 is Image wherein A is -CH2-CH2-; trans-CH=CH-; -C?C-; and R4 is linear or branched alkyl of one to twelve carbons, preferably 1-10 carbons and most preferrably 3-8 carbons, cycloalkyl of three to eight carbons; phenyl optionally substituted with one or two identical substituents selected from the group consisting of lower alkyl, lower alkoxy, hydroxy, trifluoromethyl, and halo; or optionally substituted phenylalkyl.

432390

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