3-[2-(3-amino-2-oxo-2h-pyridin-1-yl)-acetylamino]-4-oxo-pent...

Details 3-[2-(3-amino-2-oxo-2h-pyridin-1-yl)-acetylamino]-4-oxo-pent... 3-[2-(3-amino-2-oxo-2h-pyridin-1-yl)-acetylamino]-4-oxo-pent...

C - Chemistry, Metallurgy

07

D

C07D 213/74 (2006.01) A61K 31/4412 (2006.01) C07D 213/75 (2006.01) C07D 213/76 (2006.01) C07D 213/81 (2006.01) C07D 213/82 (2006.01) C07D 405/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2526749

The present invention provides a compound of formula (I), wherein R1, R6C(O)-, HC(O)-, R6SO2-, R6OC(O)-, (R6)2NC(O)-, (R6) (H) NC (O)-, R6C (O) C (O) -, R6-, (R6) 2NC (O) C (O)-, R6 (H) NC (O) C (O)-, or R6OC (O) C (O)-; R2 is hydrogen, CF3, -halo, -OR7, -NO2, -OCF3, -CN, or R8; R3 is hydrogen or (C1-C4) - aliphatic-; R4 is -COOH or -COOR8; R5 is -CH2F or -CH2O-2, 3, 5, 6- tetrafluorophenyl. The present invention also provides pharmaceutical compositions and methods using such compositions for treating a caspase- mediated diseases and processes for preparing the compounds of the invention.

L'invention concerne un composé de formule (I), pour laquelle R?1¿, R?2¿, R?3¿, R?4¿, et R?5¿ sont tels que définis dans la description, ainsi que des compositions pharmaceutiques et des procédés relatifs à l'utilisation de ces compositions pour le traitement de maladies dont la médiation est assurée par la caspase, et enfin des procédés pour la préparation des procédés décrits.

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