3-(2-haloethyl)-1,4-oxathiins and 2-(2-haloethyl)-1,...

Details 3-(2-haloethyl)-1,4-oxathiins and 2-(2-haloethyl)-1,... 3-(2-haloethyl)-1,4-oxathiins and 2-(2-haloethyl)-1,...

C - Chemistry, Metallurgy

07

D

167/242, 260/327

C07D 327/06 (2006.01) A61K 31/38 (2006.01) C07D 339/08 (2006.01)

Patent

CA 1320210

ABSTRACT Novel 3-(2-haloalkyl)-1,4-oxathiins or 2-(2-haloalkyl)- 1,4-dithiins, useful for regressing or inhibiting the growth of leukemia and tumors in mammals. The compounds have the formula: Image wherein R1 is an alkyl group containing up to 4 carbon atoms, cyclohexyl or phenyl; R2 is hydrogen or ethyl; R3 and R4 are each hydrogen, methyl or ethyl, and when either R3 or R4 is methyl or ethyl, the other is hydrogen; X is halogen: and Y is oxygen or sulfur and when Y is sulfur, R3 and R4 are both hydrogen. and pharmaceutical compositions comprising said compounds in admixture with a pharmaceutically acceptable substantially non-toxic carrier.

560945

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