3-(2-hydroxyphenyl) pyrazoles and their use as hsp90 modulators

Details 3-(2-hydroxyphenyl) pyrazoles and their use as hsp90 modulators 3-(2-hydroxyphenyl) pyrazoles and their use as hsp90 modulators

C - Chemistry, Metallurgy

07

D

C07D 231/18 (2006.01) A61K 31/415 (2006.01) A61K 31/4155 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01)

Patent

CA 2583292

The invention relates to novel phenyl pyrazole derivatives of formula (I), in which R1- R6, X and Y are defined as cited in claim 1. Said derivatives are HSP90 inhibitors and can be used for producing a medicament for treating diseases, in which the inhibition, regulation and/or modulation of HSP90 plays a role.

L'invention concerne de nouveaux dérivés de phénylpyrazole de formule (I), dans laquelle R1- R6, X et Y ont les significations données à la revendication 1, ces dérivés étant des inhibiteurs de HSP90 et pouvant servir à la réalisation d'un médicament destiné au traitement de maladies où l'inhibition, la régulation et/ou la modulation de HSP90 jouent un rôle.

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