C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/211, 260/245
C07D 237/14 (2006.01) C07D 237/08 (2006.01) C07D 237/12 (2006.01) C07D 237/20 (2006.01) C07D 403/04 (2006.01) C07D 405/12 (2006.01) C07D 413/00 (2006.01) C07D 521/00 (2006.01)
Patent
CA 1317598
NOVEL 3(2H)- PYRIDAZINONE DERIVATIVES, PHARMACEUTICAL. COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME A b s t r a c t The invention relates to novel 3(2H)-pyridazinone- -derivatives of the general formula (I), pharmaceutical compositions containing therm and process for their prepara- tion. In the general formula (I) Image (I) R stands for an ethyl or propyl group substituted by a terminal halogen atom or a hydroxyl or NR1R2 group), wherein R1 represents hydrogen atom or an unsubstituted or optionally substituted benzyl group; R2 represents hydrogen atom or an unsubstituted or optionally substituted benzo[1,4]dioxan- -2-yl-methyl or -ethyl group or a (CH2)n-R3 group, wherein n is 2 or 3; and R3 stands for an unsubstituted or optionally substituted phenoxy or phenylthio group; and stands for a hydrogen or halogen atom or an un- substituted or optionally substituted, saturated or unsaturated 5- or 6-membered heterocyclic group containing a nitrogen atom and optionally an additional heteroatom, e.g. an oxygen, sulfur or nitrogen atom, with the proviso that R is different from an ethyl or propyl group substituted terminally by a hydroxyl group or halogen atom when X represents a hydrogen or chlorides atom. The compounds of general formula (I) selectively inhibit the adrenergic alpha1 recepters, have a calcium- -antagonistic effect and exert blood pressure lowering action.
521779
Cseh Gyorgy
Czako Klara
Diesler Eszter
Elekes Istvan
Jaszlits Laszlo
Fetherstonhaugh & Co.
Richter Gedeon Vegyeszeti Gyar Rt
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