3(2h)pyridazinone, process for its preparation and...

Details 3(2h)pyridazinone, process for its preparation and... 3(2h)pyridazinone, process for its preparation and...

C - Chemistry, Metallurgy

07

D

167/224, 260/264

C07D 237/22 (2006.01) A61K 31/50 (2006.01)

Patent

CA 1324792

ABSTRACT A 3(2H)pyridazinone of the formula: Image (I) wherein R1 is hydrogen, 2-propenyl or straight chained or branched C1-C4 alkyl; R2 is hydrogen or C1-C3 alkyl; X is chlorine or bromine; Y is hydrogen, nitro, -NHR3 wherein R3 is hydrogen or straight chained or branched C1-C4 alkyl, -AR4 wherein A is oxygen or sulfur and R4 is hydrogen, straight chained or branched C1-C6 alkyl, C3-C6 alkenyl having one double bond, C3-C6 alkynyl having one triple bond, phenyl or Image wherein R5 is hydrogen or C1-C4 alkyl, or halogen: Z1 is hydrogen, C1-C4 alkyl, -OR6 wherein R6 is hydrogen, straight chained or branched C1-C8 alkyl or Image wherein n is an integer of from 1 to 4, -N(R7)2 wherein R7 is C1-C4 alkyl, or halogen; Z2 is C1-C4 alkyl, -OR6 wherein R6 is as defined above, -N(R7)2 wherein R7 is as defined above, or halogen, provided that when R1 is straight chained or branched C2-C4 alkyl, Y is not hydrogen and when R1 is hydrogen, methyl or 2-propenyl, Y and R2 are not simultaneously hydrogen, or a pharmaceutically acceptable salt thereof. These compounds exhibit antagonism against slow reacting substance of anaphylaxis (SRS-A) and are thus useful allergy treatment.

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