3,3,3-triarylalkyl-4-phenylalkyl-4-hydroxy piperidines and...

C - Chemistry – Metallurgy – 07 – D

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260/278.2, 260/2

C07D 401/06 (2006.01) C07D 211/48 (2006.01) C07D 491/10 (2006.01)

Patent

CA 1105466

Abstract of the Disclosure The present invention encompasses compounds of the formula Image and the pharmaceutically acceptable acid addition salts thereof wherein R represents hydrogen, alkanoyl having 1 to 7 carbon atoms, or lower alkyl having 1 to 7 carbon atoms; X and Y represent alkylene having 1 to 3. carbon atoms and Ar, Ar', and Ar" represent phenyl, halosubstituted phenyl, lower alkyl substituted phenyl wherein the lower alkyl contains 1 to 4 carbon atoms; and Ar"' represents phenyl, pyridyl, lower alkyl substituted phenyl wherein the lower alkyl contains 1 to 4 carbon atoms or halosubstituted phenyl. Compounds of the present invention are prepared by reaction of triarylalkanoyl halide with appropriately substituted piperidine followed by subsequent reduction of the resulting amide. Compounds of the present invention are potent antidiarrheal compounds with unexpected separation of antidiarrheal and central nervous system properties.

303828

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