C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
260/295, 260/514
C07C 59/40 (2006.01) C07C 51/29 (2006.01) C07C 59/115 (2006.01) C07C 59/66 (2006.01) C07C 59/68 (2006.01) C07C 63/72 (2006.01) C07C 69/76 (2006.01) C07D 213/30 (2006.01) C07D 213/50 (2006.01) C07D 333/08 (2006.01) C07D 333/12 (2006.01) C07D 333/28 (2006.01)
Patent
CA 1064498
ABSTRACT OF THE DISCLOSURE Fluorinated compounds of the formula: Image wherein Ar is a phenyl or naphthyl radical which, may optionally bear as substituent a halogen atom, or an alkyl or alkoxy radical of 1-4 carbon atoms, or a phenyl or phenoxy radical which may itself bear as substituent a halogen atom or an alkyl or alkoxy radical of 1-4 carbon atoms; X is a group of the formula -O.CH2- or -CH2- or a direct link between the group Ar and the adja- cent oxygen atom; R1 is a hydroxy, amino or dimethylamino radical, or an alkoxy radical of 1-6 carbon atoms optionally substituted by a carbamoyl ra- dical or an N,N-dialkylcarbamoyl or dialkylamino radical in which the alkyl radicals are of 1-6 carbon atoms, a pyridyl radical, a halophenoxy radical or a group of the formula Ar.X.O.C.(CF3)R2.CO.O-; and R2 is a hydrogen atom or an alkyl radical of 1-4 carbon atoms or a trifluoromethyl radical; or, for a compound wherein R1 is a hydroxy radical, a pharmaceutically acceptable base addition salt thereof; and their preparation by a number of conventional syntheses. The new compounds have a desirable influence on at least one of the factors involved in atherosclerotic disease, and some of the compounds show anti-arthritic properties.
241151
Haydock David B.
Mulholland Thomas P. C.
Thorp Jeffrey M.
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