3-(3,4-dioxyphenyl)-pyrrolidines as type iv...

Details 3-(3,4-dioxyphenyl)-pyrrolidines as type iv... 3-(3,4-dioxyphenyl)-pyrrolidines as type iv...

C - Chemistry, Metallurgy

07

D

C07D 207/04 (2006.01) A61K 31/40 (2006.01) A61K 31/4164 (2006.01) C07D 207/08 (2006.01) C07D 207/10 (2006.01) C07D 207/14 (2006.01) C07D 207/16 (2006.01) C07D 207/48 (2006.01) C07D 403/06 (2006.01) C07D 405/06 (2006.01)

Patent

CA 2171448

Novel pyrrolidine compounds of formula (I) which are useful for inhibiting the function of Type IV phosphodiesterase (PDE-IV) as wll as methods for making the same are disclosed. Applications in treating inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, are also disclosed.

Cette invention concerne des nouveaux composés de pyrrolidine de formule (I) qui sont utiles pour inhiber le fonctionnement de la phosphodiestérase de type IV (PDE-IV) ainsi que des procédés de production de ces derniers. Des applications de ces nouveaux composés dans le traitement des maladies inflammatoires et d'autres maladies associées à des taux élevés de cytokines, et dans le traitement des dérèglements du système nerveux central sont également décrites.

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