3-(3-amidinophenyl)-5-[({[1-(1-iminoethyl)-4-piperidyl]methy...

Details 3-(3-amidinophenyl)-5-[({[1-(1-iminoethyl)-4-piperidyl]methy... 3-(3-amidinophenyl)-5-[({[1-(1-iminoethyl)-4-piperidyl]methy...

C - Chemistry, Metallurgy

07

D

C07D 211/26 (2006.01) A61K 31/445 (2006.01) A61P 7/02 (2006.01)

Patent

CA 2436265

A process for preparing an amidine derivative represented by the following formula (II), wherein R represents a hydrogen atom or a phenyl group, which comprises reducing an amideoxime derivative represented by the following formula (I), wherein R represents a hydrogen atom or a phenyl group, with zinc in an acetic acid solvent, or a salt thereof.

L'invention concerne un procédé relatif à l'élaboration d'un dérivé d'amidine, y compris un sel correspondant, représenté par la formule (II), dans laquelle R représente un atome d'hydrogène ou un groupe phényle. Le procédé consiste à réduire un dérivé d'amide-oxime représenté par la formule (I), dans laquelle R représente un atome d'hydrogène ou un groupe phényle, avec du zinc dans un solvant à l'acide acétique.

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