3,3-disubstituted piperidines as modulators of chemokine...

Details 3,3-disubstituted piperidines as modulators of chemokine... 3,3-disubstituted piperidines as modulators of chemokine...

A - Human Necessities

61

K

A61K 31/44 (2006.01) A61K 31/438 (2006.01) A61K 31/445 (2006.01) A61K 31/4535 (2006.01) A61K 31/454 (2006.01) A61K 31/4545 (2006.01) C07D 211/06 (2006.01) C07D 211/16 (2006.01) C07D 211/20 (2006.01) C07D 211/22 (2006.01) C07D 211/76 (2006.01) C07D 401/06 (2006.01) C07D 401/14 (2006.01) C07D 471/10 (2006.01)

Patent

CA 2278309

The present invention is directed to 3,3-disubstituted piperidines of formula (I), (wherein X, Y, Z, Ar, R, m and n are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-1, CCR-2, CCR-2A, CCR-2B, CCR-3, CCR-4, CCR-5, CXCR-3, and/or CXCR-4.

La présente invention a trait à des pipéridines 3,3-disubstituées, représentées par la formule (I), (dans laquelle X, Y, Z, Ar, R, m et n sont définis dans la demande) qui sont utiles comme modulateurs de l'activité de récepteurs de chémokines. En particulier, ces composés sont utiles comme modulateurs des récepteurs CCR-1, CCR-2, CCR-2A, CCR-2B, CCR-3, CCR-4, CCR-5, CXCR-3, et/ou CXCR-4 de chémokines.

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