A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4745 (2006.01)
Patent
CA 2564561
Compounds of Formula I (wherein n, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R15, R16, R17, R18, Y and Z are as defined herein) which are modulators of chemokine receptor activity and are useful in the prevention or treatment of certain inflammatory and immunoregulatory disorders and diseases, allergic diseases, atopic conditions including allergic rhinitis, dermatitis, conjunctivitis, and asthma, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which chemokine receptors are involved.
Composés de formule I (dans laquelle n, R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?7¿, R?8¿, R?9¿, R?10¿, R?15¿, R?16¿, R?17¿, R?18¿, Y et Z sont tels que définis ici) lesquels sont des modulateurs de l'activité de récepteurs de chimiokines et sont utiles dans la prévention ou le traitement de certains troubles et maladies inflammatoires et immuno-modulateurs, de maladies allergiques, d'affections atopiques comprenant la rhinite allergique, la dermatite, la conjonctivite et l'asthme, ainsi que de pathologies auto-immunes telles que la polyarthrite rhumatoïde et l'athérosclérose. L'invention concerne également des compositions pharmaceutiques comprenant ces composés et l'utilisation de ces composés et compositions dans la prévention ou le traitement de maladies telles que celles dans lesquelles des récepteurs de chimiokines sont impliqués.
Mills Sander G.
Shankaran Kothandaraman
Yang Lihu
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
LandOfFree
3,3-disubstituted tetrahydropyranyl cyclopentyl amide... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 3,3-disubstituted tetrahydropyranyl cyclopentyl amide..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 3,3-disubstituted tetrahydropyranyl cyclopentyl amide... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1627055