3,3-disubstituted tetrahydropyranyl cyclopentyl amide...

A - Human Necessities – 61 – K

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A61K 31/4745 (2006.01)

Patent

CA 2564561

Compounds of Formula I (wherein n, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R15, R16, R17, R18, Y and Z are as defined herein) which are modulators of chemokine receptor activity and are useful in the prevention or treatment of certain inflammatory and immunoregulatory disorders and diseases, allergic diseases, atopic conditions including allergic rhinitis, dermatitis, conjunctivitis, and asthma, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which chemokine receptors are involved.

Composés de formule I (dans laquelle n, R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?7¿, R?8¿, R?9¿, R?10¿, R?15¿, R?16¿, R?17¿, R?18¿, Y et Z sont tels que définis ici) lesquels sont des modulateurs de l'activité de récepteurs de chimiokines et sont utiles dans la prévention ou le traitement de certains troubles et maladies inflammatoires et immuno-modulateurs, de maladies allergiques, d'affections atopiques comprenant la rhinite allergique, la dermatite, la conjonctivite et l'asthme, ainsi que de pathologies auto-immunes telles que la polyarthrite rhumatoïde et l'athérosclérose. L'invention concerne également des compositions pharmaceutiques comprenant ces composés et l'utilisation de ces composés et compositions dans la prévention ou le traitement de maladies telles que celles dans lesquelles des récepteurs de chimiokines sont impliqués.

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