3-¬4-(1-substituted-4-piperazinyl)butyl|-4-thiazolidinone...

Details 3-¬4-(1-substituted-4-piperazinyl)butyl|-4-thiazolidinone... 3-¬4-(1-substituted-4-piperazinyl)butyl|-4-thiazolidinone...

C - Chemistry, Metallurgy

07

D

C07D 417/14 (2006.01) A61K 31/445 (2006.01) C07D 417/12 (2006.01) C07D 513/00 (2006.01)

Patent

CA 2157348

There are disclosed compounds of the formula, Image where n is 0, 1 or 2; A is Image where X in each occurrence is independently hydrogen, halogen, loweralkyl, hydroxy, nitro, loweralkoxy, amino, cyano, trifluoromethyl or methylthio; Y in each occurrence is independently hydrogen, halogen, loweralkyl, hydroxy, nitro, loweralkoxy, amino, cyano, trifluoromethyl or methylthio; K is N or CH; m is 1 or 2; k is 1 or 2; R1 and R2 are independently hydrogen, loweralkyl, Image , Image or aryl except that when R1 is Image , Image or aryl, R2 is hydrogen, or alternatively R1 + R2 taken together with the carbon atom to which they are attached form a cyclopentane, cyclopentane, cyclohexane, cycloheptane, pyran, thiopyran, indan or piperidine ring; R3 and R4 are independently hydrogen or loweralkyl, or alternatively R3 + R4 taken together with the carbon atom to which they are attached form a cyclopentane, cyclohexane, cycloheptane, pyran, thiopyran, pyrrolidine or piperidine ring, the term aryl signifying an unsubstituted phenyl group or a phenyl group substituted with 1, 2 or 3 substituents each of which being independently loweralkyl, loweralkoxy, hydroxy, halogen, loweralkylthio, cyano, amino or trifluoromethyl, which are useful as antipsychotic, analgesic, anticonvulsant and anxiolytic agents.

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