C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/217, 260/263
C07D 417/06 (2006.01) A61K 31/495 (2006.01) C07D 277/14 (2006.01) C07D 277/60 (2006.01) C07D 277/82 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01)
Patent
CA 1317955
Abstract There are disclosed compounds of the formula, Image I where n is 0 Qr 1; A is Image or Image where X, Y, Z, U, V, W, Q, S and T are each hydrogen, halogen, loweralkyl, hydroxy, nitro, loweralkoxy, amino, cyano or trifluoromethyl; m is 1 or 2; R1 and R2 are independently hydrogen, loweralkyl or aryl, or alternatively R1 + R2 taken together with the carbon atom to which they are attached form a cyclopentane, cyclohexane, cycloheptane, pyran, thiopyran, pyrrolidine or piperidine ring; R3 and R4 are independently hydrogen or loweralkyl, or alternatively R3 + R4 taken together with the carbon atom to which they are attached form a cyclopentane, cyclohexane, cycloheptane, pyran, thiopyran, pyrrolidine or piperidine ring, the term aryl signifying an unsubstituted phenyl group or a phenyl group substituted with 1, 2 or 3 substituents each of which being independently loweralkyl, loweralkoxy, hydroxy, halogen, loweralkylthio, cyano, amino or trifluormethyl, and process for their preparation. The compounds are useful as antipsychotic, analgesic, anticonvulsant and anxiolytic agents.
583546
Hrib Nicholas J.
Jurcak John Gerard
Bereskin & Parr
Hoechst Marion Roussel Inc.
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