3-(4,5,6,7-tetrahydroindol-2-ylmethylidiene)-2-indolinone...

Details 3-(4,5,6,7-tetrahydroindol-2-ylmethylidiene)-2-indolinone... 3-(4,5,6,7-tetrahydroindol-2-ylmethylidiene)-2-indolinone...

C - Chemistry, Metallurgy

07

D

C07D 209/34 (2006.01) A61K 31/40 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) C07D 295/02 (2006.01) C07D 295/08 (2006.01) C07D 295/14 (2006.01) C07D 295/18 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2459879

The present invention relates to 3-(4,5,6,7-tetrahydroindol-2-ylmethylidene)-2- indolinone derivatives of formula I, wherein R1 R4 are defined herein, that inhibit kinases, in particular Src kinase, Pharmaceutical compositions comprising these compounds, methods of treating diseases mediated by kinase utilizing pharmaceutical compositions comprising these compounds, and methods of preparing them are also disclosed.

L'invention concerne des dérivés de 3-(4,5,6,7-tétrahydroindol-2-ylméthylidène)-2-indolinone représentés par la formule I, R1-R4 étant définis dans la demande, qui inhibent les kinases, en particulier la Src kinase ; des compositions pharmaceutiques contenant ces composés ; des procédés permettant de traiter, à l'aide de ces compositions pharmaceutiques, des maladies dans lesquelles intervient une kinase ; ainsi que des procédés de préparation de ces compositions.

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