3,4,5-trisubstituted aryl nitrone compounds and...

Details 3,4,5-trisubstituted aryl nitrone compounds and... 3,4,5-trisubstituted aryl nitrone compounds and...

C - Chemistry, Metallurgy

07

C

C07C 291/02 (2006.01) A61K 31/135 (2006.01)

Patent

CA 2353402

Disclosed are 3,4,5-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing such compounds. The 3,4,5-trisubstituted aryl nitrone compounds have formula (I); where R1-R4 are as defined in the specification. The disclosed compositions are useful as therapeutics for inflammation-related conditions in mammals, such as arthritis, and as analytical reagents for detecting free radicals.

L'invention concerne des composés de 3,4,5-arylnitrones trisubstitués et des compositions pharmaceutiques contenant lesdits composés. Les composés de 3,4,5-arylnitrones trisubstitués sont représentés par la formule (I); où R?1¿-R?4¿ sont tels que définis dans les spécifications. Ces compositions sont utiles comme thérapie pour des états inflammatoires chez les mammifères, tel que l'arthrite, et comme réactifs d'analyse permettant de détecter des radicaux.

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