3-[4-(6-{4,5-dihydroisoxazol-3-yl}pyridin-3-yl)-3-phenyl]-5-...

Details 3-[4-(6-{4,5-dihydroisoxazol-3-yl}pyridin-3-yl)-3-phenyl]-5-... 3-[4-(6-{4,5-dihydroisoxazol-3-yl}pyridin-3-yl)-3-phenyl]-5-...

C - Chemistry, Metallurgy

07

D

C07D 413/14 (2006.01) A61K 31/4192 (2006.01) A61K 31/422 (2006.01) A61K 31/4427 (2006.01) A61P 31/04 (2006.01)

Patent

CA 2567454

Compounds of the formula (I): or a pharmaceutically- acceptable salt or pro- drug thereof: wherein R1 is selected for example from hydrogen, halogen, optionally substituted methyl; R2 and R3 are independently selected from hydrogen, fluoro, chloro and trifluoromethyl;R4 and R5 are independently selected, for example, from hydrogen, methyl, optionally substituted (2- 4C)alkyl , C(O)R6 or R4 and R5 together with the nitrogen to which they are attached form an optionally substituted 5 or 6 membered, saturated or partially unsaturated heterocyclyl ring or an optionally substituted imidazole ring. Methods for making the compounds of formula (I), compositions containing them and their use as antibacterial agents are also described.

Des composés représentés par la formule générale (I), ou certains de leurs sels ou promédicaments pharmaceutiquement admis. Dans cette formule, R?1¿ est notamment, au choix, hydrogène, halogène ou méthyle éventuellement substitué. R?2¿ et R?3¿ sont indépendamment, au choix, hydrogène, fluoro, chloro ou trifluorométhyle. R?4¿ et R?5¿ sont indépendamment, au choix, hydrogène, méthyle, (2-4C)alkyle éventuellement substitué ou C(O)R?6¿. Toutefois, R?4¿ et R?5¿ forment, avec l'azote auquel ils sont attachés, soit un noyau hétérocyclique saturé ou partiellement insaturé à 5 ou 6 segments, éventuellement substitué, soit un noyau imidazole éventuellement substitué. L'invention concerne également des procédés de fabrication des composés de l'invention, des compositions les contenant, et leur utilisation comme bactéricides.

Affiliated with

Also associated with

Rating

3-[4-(6-{4,5-dihydroisoxazol-3-yl}pyridin-3-yl)-3-phenyl]-5-... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 3-[4-(6-{4,5-dihydroisoxazol-3-yl}pyridin-3-yl)-3-phenyl]-5-..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 3-[4-(6-{4,5-dihydroisoxazol-3-yl}pyridin-3-yl)-3-phenyl]-5-... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1818763