3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octan...

Details 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octan... 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octan...

A - Human Necessities

61

K

A61K 31/519 (2006.01) A61P 17/00 (2006.01) A61P 27/02 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 37/06 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2761954

The present invention relates to the Janus kinase (JAK) inhibitors 3-[4-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)-1H-pyrazol-l-yl]octanenitrile or 3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-y1)-1H- pyrazol-l-yl]heptanenitrile, as well as its compositions and methods of use, which is useful in the treatment of JAK-associated diseases including, for example, inflammatory and autoimmune disorders, skin disorders, cancer, and other diseases.

La présente invention porte sur des inhibiteurs de la kinase Janus (JAK) 3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-l-yl]octanenitrile ou 3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-y1)-1H-pyrazol-l-yl]heptanenitrile, ainsi que sur leurs compositions et leurs procédés d'utilisation, qui sont utiles dans le traitement de maladies associées à JAK comprenant, par exemple, des troubles inflammatoires et auto-immunitaires, des troubles de la peau, un cancer et autres maladies.

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