3,4-di-substituted cyclobutene-1, 2-diones as cxc chemokine...

Details 3,4-di-substituted cyclobutene-1, 2-diones as cxc chemokine... 3,4-di-substituted cyclobutene-1, 2-diones as cxc chemokine...

C - Chemistry, Metallurgy

07

C

C07C 225/20 (2006.01) A61K 31/136 (2006.01) A61K 31/166 (2006.01) C07C 229/42 (2006.01) C07C 229/64 (2006.01) C07C 237/36 (2006.01) C07C 237/44 (2006.01) C07C 255/58 (2006.01) C07C 255/59 (2006.01) C07C 271/20 (2006.01) C07C 311/08 (2006.01) C07C 311/21 (2006.01) C07D 205/04 (2006.01) C07D 207/08 (2006.01) C07D 207/16 (2006.01) C07D 211/60 (2006.01) C07D 213/74 (2006.01) C07D 213/89 (2006.01) C07D 231/38 (2006.01) C07D 235/06 (2006.01) C07D 239/42 (2006.01) C07D 249/18 (2006.01) C07D 277/28 (2006.01) C07D 2

Patent

CA 2436351

There are disclosed compounds of formula (I) wherein the variables A and B are an aryl or heteroaryl group as defined in the claims, or a prodrug thereof, or a pharmaceutically acceptable salt, solvate or isomer of said compound or of said prodrug, which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.

La présente invention concerne des composés de formule (I), dans laquelle les variables A et B sont du groupe aryle or hétéroarlye ainsi que défini dans les revendications ou un prodrogue de ceux-ci, ou un sel, un solvate ou isomère pharmaceutiquement acceptable dudit composé ou dudit prodrogue, utiles pour le traitement de maladies liées à la chimiokine telles que des troubles inflammatoires aigus et chroniques et le cancer.

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