3,4-diamino-3-cyclobutene-1,2-dione derivatives which...

Details 3,4-diamino-3-cyclobutene-1,2-dione derivatives which... 3,4-diamino-3-cyclobutene-1,2-dione derivatives which...

C - Chemistry, Metallurgy

07

C

C07C 225/20 (2006.01) A61K 31/13 (2006.01) A61P 29/00 (2006.01) C07C 221/00 (2006.01) C07C 229/46 (2006.01) C07C 271/00 (2006.01) C07C 271/44 (2006.01) C07D 209/14 (2006.01) C07D 213/38 (2006.01) C07D 213/82 (2006.01) C07D 295/116 (2006.01) C07D 295/135 (2006.01) C07D 295/185 (2006.01) C07D 295/205 (2006.01)

Patent

CA 2351464

Compounds of formula (I) which inhibit leukocyte adhesion mediated by interaction of the .alpha.4.beta.1 integrin (VLA-4) with its counterreceptor VCAM-1, and their use for the treatment of inflammatory and autoimmune diseases.

L'invention concerne des composés de formule (I), dont l'adhérence aux leucocytes a pour origine l'interaction de l'intégrine .alpha.¿4?.beta.¿1? (VLA-4) et de son contre-récepteur VCAM-1. Cette invention concerne également l'utilisation de ces composés pour traiter les maladies inflammatoires et auto-immunes.

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