C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/04 (2006.01) A61K 31/538 (2006.01) A61K 45/00 (2006.01) A61P 1/04 (2006.01) A61P 3/10 (2006.01) A61P 9/10 (2006.01) A61P 13/02 (2006.01) A61P 13/10 (2006.01) A61P 17/00 (2006.01) A61P 17/02 (2006.01) A61P 17/04 (2006.01) A61P 19/02 (2006.01) A61P 25/00 (2006.01) A61P 25/04 (2006.01) A61P 25/06 (2006.01) A61P 27/16 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 37/08 (2006.01) C07D 413/14 (2006.01)
Patent
CA 2632508
Disclosed is a 3,4-dihydrobenzoxazine compound represented by the formula [1] below, which is useful for the treatment of a disease associated with the activity of a vanilloid receptor type 1 (VR1) such as pain, wherein X represents a nitrogen atom or CR3; R1 represents a hydrogen or halogen atom; R2 represents a C1-6 alkoxy group which may be substituted by 1 to 5 substituents independently selected from a halogen atom and a hydroxyl group; and R3 represents a halogen atom, provided that R1 is a halogen atom when X is CR3.
La présente invention concerne un composé de 3,4-dihydrobenzoxazine représenté par la formule [1] ci-dessous, qui est utile pour le traitement d'une maladie associée à l'activité d'un récepteur de vanilloïde de type 1 (VR1) telle que la douleur. [1] où X représente un atome d'azote ou CR3 ; R1 représente un atome d'hydrogène ou d'halogène ; R2 représente un groupe alcoxy en C1-6 qui peut être substitué par 1 à 5 substituants indépendamment choisis parmi un atome d'halogène et un groupe hydroxyle ; et R3 représente un atome d'halogène, à condition que R1 soit un atome d'halogène lorsque X est CR3.
Hori Yoshikazu
Koga Yoshihisa
Kondo Wataru
Matsumoto Tatsuya
Sakata Masahiro
Japan Tobacco Inc.
Ridout & Maybee Llp
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