C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 217/16 (2006.01) A61K 31/4365 (2006.01) A61K 31/472 (2006.01) A61K 31/4725 (2006.01) A61K 31/473 (2006.01) A61K 31/4747 (2006.01) A61K 31/497 (2006.01) A61K 31/536 (2006.01) A61K 31/5377 (2006.01) A61P 11/06 (2006.01) A61P 17/00 (2006.01) A61P 25/04 (2006.01) A61P 27/16 (2006.01) A61P 29/00 (2006.01) A61P 37/04 (2006.01) A61P 37/06 (2006.01) A61P 37/08 (2006.01) C07D 217/18 (2006.01) C07D 217/24 (2006.01) C07D 221/20 (2006.01) C07D 265/14 (2006.01) C07D 265/16 (2006.01) C07D 401/04 (2006.01) C07D 401/0
Patent
CA 2417156
3,4-Dihydroisoquinoline derivative compounds represented by the following general formula (I) (wherein each symbol has the meaning as specified in the description) or nontoxic salts thereof. Because of having a CB2 receptor agonist activity, the compounds represented by the general formula (I) are useful in preventing and/or treating various diseases, for example, asthma, nasal allergy, atopic dermatitis, autoimmune diseases, rheumatish, immnodeficiency, postoperative pain and carcinomatous pain.
La présente invention concerne des composés dérivés de 3,4-dihydroisoquinoline représentés par la formule générale (I) suivante, dans laquelle chaque symbole est tel que décrit dans les spécifications. Comme ces composés possèdent une activité antagoniste du récepteur CB2, ils conviennent pour la prévention et/ou le traitement de diverses maladies, par exemple l'asthme, les allergie nasales, les dermites atopiques, les maladies auto-immunes, les rhumatismes, l'immunodéficience, les douleurs post opératoires et les douleurs carcinomateuses.
Ogawa Mikio
Ohhata Akira
Takaoka Yoshikazu
Ono Pharmaceutical Co. Ltd.
Riches Mckenzie & Herbert Llp
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