3,4-dihydropyrimidine trpa1 antagonists

Details 3,4-dihydropyrimidine trpa1 antagonists 3,4-dihydropyrimidine trpa1 antagonists

C - Chemistry, Metallurgy

07

D

C07D 239/22 (2006.01) A61K 31/517 (2006.01) A61K 31/519 (2006.01) A61P 29/00 (2006.01) C07D 401/04 (2006.01) C07D 405/04 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2724878

The present invention is related to novel 3,4-dihydropyrimidine compounds of formula (I) having TRPA1 receptor antagonistic properties, pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their use in the treatment of diseases linked to the modulation of the TRPA1 receptors in animals, in particular humans.

La présente invention porte sur de nouveaux composés 3,4-dihydropyrimidines représentés par la formule (I) ayant des propriétés antagonistes des récepteurs TRPA1, sur des compositions pharmaceutiques comprenant ces composés, sur des procédés chimiques pour préparer ces composés et sur leur utilisation dans le traitement de maladies liées à la modulation des récepteurs TRPA1 chez les animaux, en particulier les êtres humains.

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