C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/06 (2006.01) A61K 31/4709 (2006.01) A61P 25/28 (2006.01)
Patent
CA 2483636
This invention provides a compound which is (R)-6-[2-[ 4-(3- fluorophenyl)- 4- hydroxy-l-piperidinyl]-1-hydroxyethyl]-3,4-dihydro-2(1 H)-quinolinon or a 5 pharmaceutically acceptable ester of such compound, or a pharmaceutically acceptable salt thereof. The compound is useful for the treatment of disease conditions caused by overactivation of NMDA NR2B receptor such of pain, stroke, traumatic brain injury, Parkinson's disease, Alzheimer's disease, depression, anxiety, migraine, or the like in mammalian, especially humans. This invention also 10 provides a pharmaceutical composition comprising the above compound.
La présente invention concerne un composé qui est un (R)-6-[2-[ 4-(3- fluorophényl)- 4-hydroxy-l-pipéridinyl]-1-hydroxyéthyl]-3,4-dihydro-2(1 H)-quinolinone ou un ester pharmaceutiquement acceptable de ce composé, ou un sel pharmaceutiquement acceptable de ce dernier. Ce composé permet de traiter des conditions maladives provoquées par la suractivation du récepteur NMDA NR2B comme la douleur, l'accident vasculaire cérébral, les blessures traumatiques du cerveau, la maladie de Parkinson, la maladie d'Alzheimer, la dépression, l'anxiété, la migraine ou similaire chez le mammifère, en particulier, chez l'homme. La présente invention traite également d'une composition pharmaceutique comprenant le composé susmentionné.
Pfizer Inc.
Smart & Biggar
LandOfFree
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