(3,4-disubstituted)propanoic carboxylates as s1p (edg)...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 271/06 (2006.01) A61K 31/4245 (2006.01) A61K 31/427 (2006.01) A61K 31/443 (2006.01) A61K 31/506 (2006.01) C07D 413/04 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2547198

The present invention encompasses compounds of Formula A: A as well as the pharmaceutically acceptable salts thereof. The compounds are S1P1/Edg1 receptor agonists and thus have immunosuppressive, anti-inflammatory and hemostatic activities by modulating leukocyte trafficking, sequestering lymphocytes in secondary lymphoid tissues, and enhancing vascular integrity. The invention is also directed to pharmaceutical compositions containing such compounds and methods of treatment or prevention.

L'invention concerne des composés de formule (A) et leurs sels pharmaceutiquement acceptables. Les composés sont des agonistes du récepteur S1P¿1?/Edg1 et présentent ainsi des activités hémostatiques, anti-inflammatoires et immunosuppressives par modulation du trafic des leucocytes, séquestration des lymphocytes dans des tissus lymphoïdes secondaires, et amélioration de l'intégrité vasculaire. L'invention concerne également des compositions pharmaceutiques contenant lesdits composés et des méthodes de traitement ou de prévention.

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